Title : Enhanced expression of Gqα and PLC-β1 proteins contributes to vascular smooth muscle cell hypertrophy in SHR: role of endogenous angiotensin II and endothelin-1.

Pub. Date : 2014 Jul 1

PMID : 24760983






1 Functional Relationships(s)
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1 In addition, the enhanced expression of Gqalpha/PLC-beta1 proteins, enhanced phosphorylation of ERK1/2, and enhanced protein synthesis in VSMC from SHR were attenuated by the ANG II AT1 and endothelin-1 (ET-1) ETA receptor antagonists losartan and BQ123, respectively, but not by the ETB receptor antagonist BQ788. Losartan angiotensin II receptor, type 1a Rattus norvegicus