Pub. Date : 2014 Apr 23
PMID : 24760190
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that the effect of aspirin may be antagonized by low 15-PGDH expression in the normal colon. | Aspirin | 15-hydroxyprostaglandin dehydrogenase | Homo sapiens |
| 2 | Compared with nonuse, regular aspirin use was associated with lower risk of colorectal cancer that developed within a background of colonic mucosa with high 15-PGDH expression [multivariable HR, 0.49; 95% confidence interval (CI), 0.34 to 0.71], but not with low 15-PGDH expression (multivariable HR, 0.90; 95% CI, 0.63 to 1.27) (P for heterogeneity = 0.018). | Aspirin | 15-hydroxyprostaglandin dehydrogenase | Homo sapiens |
| 3 | Compared with nonuse, regular aspirin use was associated with lower risk of colorectal cancer that developed within a background of colonic mucosa with high 15-PGDH expression [multivariable HR, 0.49; 95% confidence interval (CI), 0.34 to 0.71], but not with low 15-PGDH expression (multivariable HR, 0.90; 95% CI, 0.63 to 1.27) (P for heterogeneity = 0.018). | Aspirin | 15-hydroxyprostaglandin dehydrogenase | Homo sapiens |
| 4 | Regular aspirin use was associated with lower incidence of colorectal cancers arising in association with high 15-PGDH expression, but not with low 15-PGDH expression in normal colon mucosa. | Aspirin | 15-hydroxyprostaglandin dehydrogenase | Homo sapiens |
| 5 | This suggests that 15-PGDH expression level in normal colon mucosa may serve as a biomarker that may predict stronger benefit from aspirin chemoprevention. | Aspirin | 15-hydroxyprostaglandin dehydrogenase | Homo sapiens |