Title : TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.

Pub. Date : 2014 Jun 1

PMID : 24760149






3 Functional Relationships(s)
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1 Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens
2 Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens
3 Poly(I:C) stimulated translocation of NF-kappaB and IRF-3 into the nucleus in fibroblasts and inhibition of NF-kappaB or IRF-3 abrogated the poly(I:C)-induced increase in both iNOS expression and release of MMPs. Poly I-C nuclear factor kappa B subunit 1 Homo sapiens