Pub. Date : 2014 Jul 25
PMID : 24759273
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Colchicine effect on P-glycoprotein expression and activity: in silico and in vitro studies. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Colchicine is a P-glycoprotein (P-gp) substrate that induces its expression, thus increasing the risk for unexpected pharmacokinetic interactions with this drug. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Colchicine is a P-glycoprotein (P-gp) substrate that induces its expression, thus increasing the risk for unexpected pharmacokinetic interactions with this drug. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Because increased P-gp expression does not always correlate with increased activity of this efflux pump, we evaluated the changes in both P-gp expression and activity induced by colchicine using an in vitro model. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Furthermore, colchicine fitting in P-gp induction and competitive inhibition pharmacophore hypothesis, and docking studies evaluating the interaction between colchicine and P-gp drug binding pocket were tested in silico. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Furthermore, colchicine fitting in P-gp induction and competitive inhibition pharmacophore hypothesis, and docking studies evaluating the interaction between colchicine and P-gp drug binding pocket were tested in silico. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Moreover, colchicine significantly increased P-gp ATPase activity, demonstrating to be actively transported by the pump. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | Colchicine fitted both the P-gp induction and competitive inhibition models. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | In silico, colchicine was predicted to bind to the P-gp drug-binding pocket suggesting a competitive mechanism of transport. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | These results show that colchicine induced P-gp expression in Caco-2 cells but the activity of the protein remained unchanged, highlighting the need to simultaneously evaluate P-gp expression and activity. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 11 | These results show that colchicine induced P-gp expression in Caco-2 cells but the activity of the protein remained unchanged, highlighting the need to simultaneously evaluate P-gp expression and activity. | Colchicine | ATP binding cassette subfamily B member 1 | Homo sapiens |