Title : Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension.

Pub. Date : 2013 Dec 1

PMID : 24744867






5 Functional Relationships(s)
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Protein Name
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1 Thrombin treatment of PASMC resulted in a transient increase in Akt phosphorylation and had similar effects on the downstream targets of the Akt/mTOR pathway. pasmc AKT serine/threonine kinase 1 Homo sapiens
2 Thrombin treatment of PASMC resulted in a transient increase in Akt phosphorylation and had similar effects on the downstream targets of the Akt/mTOR pathway. pasmc AKT serine/threonine kinase 1 Homo sapiens
3 Enhanced proliferation is also shown to be attenuated by inhibition of Akt/mTOR in CTEPH PASMC. pasmc AKT serine/threonine kinase 1 Homo sapiens
4 Thrombin has direct effects on PASMC increasing intracellular [Ca(2+)] and PASMC proliferation, an effect attributed to Akt phosphorylation. pasmc AKT serine/threonine kinase 1 Homo sapiens
5 Thrombin has direct effects on PASMC increasing intracellular [Ca(2+)] and PASMC proliferation, an effect attributed to Akt phosphorylation. pasmc AKT serine/threonine kinase 1 Homo sapiens