Title : Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation.

Pub. Date : 2014 Apr 17

PMID : 24743742






1 Functional Relationships(s)
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1 Treatment with TNF-alpha/IL-1beta inhibited BMP-2-induced alkaline phosphatase activity, calcium deposition, osteogenic transcriptional factor Runx2, and the expression of osteogenic markers in C2C12 and MC3T3-E1 cells. Calcium interleukin 1 beta Mus musculus