Title : Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli.

Pub. Date : 1989 Jul

PMID : 2474353






3 Functional Relationships(s)
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1 Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. Histamine immunoglobulin heavy constant epsilon Homo sapiens
2 Challenge of gradient fractions with epsilon-chain-specific anti-human IgE stimulated the release of histamine, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4). Histamine immunoglobulin heavy constant epsilon Homo sapiens
3 These studies suggest that IgE-dependent and non-immunological stimuli activate human skin mast cells by different secretory mechanisms, a hypothesis supported by our previous findings of differences in Ca2+ requirements and time-course of histamine release. Histamine immunoglobulin heavy constant epsilon Homo sapiens