Title : CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients.

Pub. Date : 2014 Dec

PMID : 24739669






1 Functional Relationships(s)
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1 We thus assessed the role of genetic variation in CYP3A4, CYP3A5, POR, NR1I2, and ABCB1 acting jointly in immunosuppressive drug pathways in tacrolimus (TAC) and ciclosporin (CSA) dose requirement in HTx recipients. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens