Title : TNF-alpha mediated selection of macrophage-resistant gene-regulatory tumor variants.

Pub. Date : 1989 Sep-Oct

PMID : 2473862






2 Functional Relationships(s)
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1 In vitro macrophage- or TNF-alpha-mediated selection procedures on 3LL tumor cells have led to the selection of 3LL variants manifesting a highly reduced sensitivity towards the cytotoxic effects of both TNF-alpha and tumoricidal macrophages, while retaining the parental sensitivity to the cytolytic activity of (i) H2O2, (ii) macrophage-ADCC reactions and (iii) NK cells. Hydrogen Peroxide tumor necrosis factor Mus musculus
2 In vitro macrophage- or TNF-alpha-mediated selection procedures on 3LL tumor cells have led to the selection of 3LL variants manifesting a highly reduced sensitivity towards the cytotoxic effects of both TNF-alpha and tumoricidal macrophages, while retaining the parental sensitivity to the cytolytic activity of (i) H2O2, (ii) macrophage-ADCC reactions and (iii) NK cells. Hydrogen Peroxide tumor necrosis factor Mus musculus