Pub. Date : 2014 Feb
PMID : 24738138
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis. | Histamine | G protein-coupled receptor kinase 2 | Homo sapiens |
2 | Microscopic and biochemical analyses of Weibel-Palade body (WPB) formation and functioning, live cell imaging of calcium concentrations and video analyses of adhesion of monocyte-like THP-1 cells provide clear evidence of GRK2 function in histamine activation of endothelial cells. | Histamine | G protein-coupled receptor kinase 2 | Homo sapiens |
3 | RESULTS: G protein-coupled receptor kinase 2 depletion in HUVECs increases WPB exocytosis and P-selectin-dependent adhesion of THP-1 cells to the endothelial surface upon histamine stimulation, relative to controls. | Histamine | G protein-coupled receptor kinase 2 | Homo sapiens |