Title : G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis.

Pub. Date : 2014 Feb

PMID : 24738138






3 Functional Relationships(s)
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1 G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis. Histamine G protein-coupled receptor kinase 2 Homo sapiens
2 Microscopic and biochemical analyses of Weibel-Palade body (WPB) formation and functioning, live cell imaging of calcium concentrations and video analyses of adhesion of monocyte-like THP-1 cells provide clear evidence of GRK2 function in histamine activation of endothelial cells. Histamine G protein-coupled receptor kinase 2 Homo sapiens
3 RESULTS: G protein-coupled receptor kinase 2 depletion in HUVECs increases WPB exocytosis and P-selectin-dependent adhesion of THP-1 cells to the endothelial surface upon histamine stimulation, relative to controls. Histamine G protein-coupled receptor kinase 2 Homo sapiens