Title : Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis.

Pub. Date : 2014

PMID : 24736568






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 E2-dependent activation of GPER-1 lowers testosterone production in isolated rats LCs and in human testis, with statistically and clinically significant drops in testosterone production by 20-30% as compared to estradiol-naive LC. Testosterone G protein-coupled estrogen receptor 1 Rattus norvegicus
2 E2-dependent activation of GPER-1 lowers testosterone production in isolated rats LCs and in human testis, with statistically and clinically significant drops in testosterone production by 20-30% as compared to estradiol-naive LC. Testosterone G protein-coupled estrogen receptor 1 Rattus norvegicus
3 CONCLUSIONS: Our results indicate that activation of GPER-1 lowers testosterone levels in the rat and human testis. Testosterone G protein-coupled estrogen receptor 1 Rattus norvegicus