Title : Inhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound.

Pub. Date : 2014 Jun

PMID : 24729544






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibitors of cathepsin K, Cbz-Leu-NHCH2 CN (2) and Cbz-Leu-Ser(OBn)-CN (3), were caged within the complexes cis-[Ru(bpy)2 (2)2 ]Cl2 (4) and cis-[Ru(bpy)2 (3)2 ](BF4 )2 (5) (bpy=2,2"-bipyridine) as 1:1 mixtures of Delta and Lambda stereoisomers. 2,2'-Dipyridyl cathepsin K Homo sapiens
2 Inhibitors of cathepsin K, Cbz-Leu-NHCH2 CN (2) and Cbz-Leu-Ser(OBn)-CN (3), were caged within the complexes cis-[Ru(bpy)2 (2)2 ]Cl2 (4) and cis-[Ru(bpy)2 (3)2 ](BF4 )2 (5) (bpy=2,2"-bipyridine) as 1:1 mixtures of Delta and Lambda stereoisomers. 2,2'-Dipyridyl cathepsin K Homo sapiens