Title : Comparison of effects of pioglitazone and glimepiride on plasma soluble RAGE and RAGE expression in peripheral mononuclear cells in type 2 diabetes: randomized controlled trial (PioRAGE).

Pub. Date : 2014 Jun

PMID : 24727234






2 Functional Relationships(s)
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1 Furthermore, RAGE expression in mononuclear cells was significantly (p = 0.008) decreased to a greater degree in the pioglitazone group at 24 weeks (-7.39 +- 5.18 vs. -3.39 +- 5.72 MFI). Pioglitazone advanced glycosylation end-product specific receptor Homo sapiens
2 CONCLUSION: Pioglitazone suppresses RAGE expression and increases circulating sRAGE/esRAGE, and those activities are not necessarily dependent on plasma glucose or insulin resistance levels. Pioglitazone advanced glycosylation end-product specific receptor Homo sapiens