Title : Melatonin receptor type 1 signals to extracellular signal-regulated kinase 1 and 2 via Gi and Gs dually coupled pathways in HEK-293 cells.

Pub. Date : 2014 May 6

PMID : 24724723






3 Functional Relationships(s)
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1 In this study, using HEK293 cells stably expressing the human MT1 receptor, melatonin induced a concentration-dependent activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2). Melatonin mitogen-activated protein kinase 3 Homo sapiens
2 The melatonin-mediated phosphorylation of ERK1/2 at later time points (>=5 min) was strongly suppressed by pretreatment with pertussis toxin, but only a slight, if any, inhibition of ERK1/2 activation at early time points (<=2 min) was detected. Melatonin mitogen-activated protein kinase 3 Homo sapiens
3 The melatonin-mediated phosphorylation of ERK1/2 at later time points (>=5 min) was strongly suppressed by pretreatment with pertussis toxin, but only a slight, if any, inhibition of ERK1/2 activation at early time points (<=2 min) was detected. Melatonin mitogen-activated protein kinase 3 Homo sapiens