Pub. Date : 2014
PMID : 24723845
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotinamide has been proposed as a suitable PARP-1 inhibitor. | Niacinamide | poly (ADP-ribose) polymerase 1 | Rattus norvegicus |
| 2 | Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles. | Niacinamide | poly (ADP-ribose) polymerase 1 | Rattus norvegicus |
| 3 | Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles. | Niacinamide | poly (ADP-ribose) polymerase 1 | Rattus norvegicus |