Pub. Date : 2014 Aug
PMID : 24723470
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |
| 2 | UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |
| 3 | ABCB4-mediated PC secretion was also increased by pharmacological activation of protein kinases A or C and decreased by inhibition of these kinases. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |
| 4 | CONCLUSION: We identified disease-associated variants of ABCB4 involved in the phosphorylation of its N-terminal domain and leading to decreased PC secretion. | Phosphatidylcholines | ATP binding cassette subfamily B member 4 | Homo sapiens |