Title : Antitumor effect of angiotensin II type 1 receptor blocker losartan for orthotopic rat pancreatic adenocarcinoma.

Pub. Date : 2014 Aug

PMID : 24717824






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1 CONCLUSIONS: The results of this study indicate that combined treatment with gemcitabine and losartan significantly improved the survival of rats with orthotopic pancreatic cancer by inhibiting vascular endothelial growth factor synthesis and suppressing cancer cell proliferation via AT1 receptor blockade. Losartan angiotensin II receptor, type 1a Rattus norvegicus