Title : Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels.

Pub. Date : 2014 May

PMID : 24709058






1 Functional Relationships(s)
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1 Hesperidin (4"-methoxy-7-O-rutinosyl-3",5-dihydroxyflavanone), a naturally occurring flavanone glycoside, was previously shown to produce an antidepressant-like effect with modultation of the serotonergic 5-HT1A and kappa-opioid receptors. Hesperidin 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus