Title : The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

Pub. Date : 2014 Nov 15

PMID : 24706440






1 Functional Relationships(s)
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1 By structure-function analysis of ROR1 mutants, we show that ROR1 encompasses two major substrate regions: one is located in the proline-rich domain and is directly phosphorylated by MET; the other resides in the pseudokinase domain and is phosphorylated through intermediate activation of SRC. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens