Title : Regulation of hepatic insulin receptor activity following injury.

Pub. Date : 2014 May 15

PMID : 24699331






2 Functional Relationships(s)
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1 These findings suggest that a balance between O-GlcNac modification and JNK-induced phosphorylation may exist, with decreased Ser/Thr O-GlcNac modification following trauma and hemorrhage, allowing JNK to phosphorylate the IR on neighboring Ser/Thr residues, which subsequently inhibits IR activity. Serine mitogen-activated protein kinase 8 Homo sapiens
2 These findings suggest that a balance between O-GlcNac modification and JNK-induced phosphorylation may exist, with decreased Ser/Thr O-GlcNac modification following trauma and hemorrhage, allowing JNK to phosphorylate the IR on neighboring Ser/Thr residues, which subsequently inhibits IR activity. Serine mitogen-activated protein kinase 8 Homo sapiens