Pub. Date : 2014 May
PMID : 24691444
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate"s protective effect in EAE. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 2 | DMF and, more so, its active metabolite, monomethyl fumarate, are known agonists of the hydroxycarboxylic acid receptor 2 (HCA2), a G protein-coupled membrane receptor. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 3 | DMF and, more so, its active metabolite, monomethyl fumarate, are known agonists of the hydroxycarboxylic acid receptor 2 (HCA2), a G protein-coupled membrane receptor. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 4 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 5 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 6 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 7 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 8 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 9 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 10 | Here, we evaluated the contribution of HCA2 in mediating the protective effect afforded by DMF in EAE, a mouse model of MS. DMF treatment reduced neurological deficit, immune cell infiltration, and demyelination of the spinal cords in wild-type mice, but not in Hca2-/- mice, indicating that HCA2 is required for the therapeutic effect of DMF. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 11 | In particular, DMF decreased the number of infiltrating neutrophils in a HCA2-dependent manner, likely by interfering with neutrophil adhesion to endothelial cells and chemotaxis. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 12 | Together, our data indicate that HCA2 mediates the therapeutic effects of DMF in EAE. | Dimethyl Fumarate | hydroxycarboxylic acid receptor 2 | Mus musculus |