Pub. Date : 2014 Mar-Apr
PMID : 24681787
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H2O2 evokes injury of cardiomyocytes through upregulating HMGB1. | Hydrogen Peroxide | high mobility group box 1 | Rattus norvegicus |
| 2 | This study aimed to investigate the role of high-mobility group box 1 protein (HMGB1) in cardiomyocytes undergoing H2O2 treatment. | Hydrogen Peroxide | high mobility group box 1 | Rattus norvegicus |
| 3 | This study aimed to investigate the role of high-mobility group box 1 protein (HMGB1) in cardiomyocytes undergoing H2O2 treatment. | Hydrogen Peroxide | high mobility group box 1 | Rattus norvegicus |
| 4 | RESULTS: H2O2-induced ROS significantly decreased cell viability, promoted the apoptosis of neonatal myocytes, and upregulated the expression of HMGB1 in a dose-dependent manner. | Hydrogen Peroxide | high mobility group box 1 | Rattus norvegicus |
| 5 | However, NAC or HMGB1 neutralizing antibody suppressed the loss of cell viability and the rate of cell apoptosis induced by H2O2. | Hydrogen Peroxide | high mobility group box 1 | Rattus norvegicus |
| 6 | CONCLUSION: The present study suggests that H2O2-induced ROS evoke injury to cardiomyocytes that may be associated with upregulating HMGB1. | Hydrogen Peroxide | high mobility group box 1 | Rattus norvegicus |