Title : The dopamine transporter expression level differentially affects responses to cocaine and amphetamine.

Pub. Date : 2014 Mar-Jun

PMID : 24673634






6 Functional Relationships(s)
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1 The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. Cocaine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
2 Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and cause psychomotor effects, they have very different mechanisms of actions. Cocaine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
3 Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and cause psychomotor effects, they have very different mechanisms of actions. Cocaine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
4 In the constitutive DAT knockdown mice, reduced DAT expression enhanced cocaine"s locomotor stimulatory effects and at the same time diminished amphetamine"s locomotor stimulatory effects. Cocaine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
5 In the constitutive DAT knockdown mice, reduced DAT expression enhanced cocaine"s locomotor stimulatory effects and at the same time diminished amphetamine"s locomotor stimulatory effects. Cocaine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
6 The authors propose that responses to cocaine and amphetamine depend on psychostimulant drug type, drug dose, as well as DAT expression level. Cocaine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus