Pub. Date : 2014 Mar-Jun
PMID : 24673634
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. | Amphetamine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 2 | Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and cause psychomotor effects, they have very different mechanisms of actions. | Amphetamine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 3 | Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and cause psychomotor effects, they have very different mechanisms of actions. | Amphetamine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 4 | In the constitutive DAT knockdown mice, reduced DAT expression enhanced cocaine"s locomotor stimulatory effects and at the same time diminished amphetamine"s locomotor stimulatory effects. | Amphetamine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 5 | Whereas amphetamine-induced increase in extracellular dopamine was drastically diminished in constitutive DAT knockdown mice, cocaine-induced increase in extracellular dopamine had a faster onset in knockdown mice compared with wild-type controls. | Amphetamine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 6 | The authors propose that responses to cocaine and amphetamine depend on psychostimulant drug type, drug dose, as well as DAT expression level. | Amphetamine | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |