Title : IGF-1 induces iNOS expression via the p38 MAPK signal pathway in the anti-apoptotic process in pulmonary artery smooth muscle cells during PAH.

Pub. Date : 2014 Aug

PMID : 24673524






4 Functional Relationships(s)
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1 In this study, we investigated the involvement of iNOS in the process of IGF-1-induced inhibition of PASMC apoptosis. pasmc insulin like growth factor 1 Homo sapiens
2 Our results show that exogenous IGF-1 induced the up-regulation of iNOS in PASMC. pasmc insulin like growth factor 1 Homo sapiens
3 iNOS inhibition in PASMC in vitro markedly induced IGF-1-mediated anti-apoptosis as assessed by the cell viability measurement, Western blot, mitochondrial potential analysis and nuclear morphology determination. pasmc insulin like growth factor 1 Homo sapiens
4 Our findings suggest that IGF-1 inhibits cells apoptosis in PASMC by activating the p38 MAPK-iNOS transduction pathway. pasmc insulin like growth factor 1 Homo sapiens