Title : Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.

Pub. Date : 2014 Jun

PMID : 24657625






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Lactic Acid hydrocarboxylic acid receptor 1 Mus musculus
2 The administration of lactate reduced inflammation and organ injury in mice with immune hepatitis; this reduction required Gpr81 dependence in vivo. Lactic Acid hydrocarboxylic acid receptor 1 Mus musculus
3 CONCLUSIONS: Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81. Lactic Acid hydrocarboxylic acid receptor 1 Mus musculus