Title : Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.

Pub. Date : 2014 Jun

PMID : 24657625






1 Functional Relationships(s)
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1 RESULTS: In macrophages and monocytes, increasing concentrations of lactate reduced TLR4-mediated induction of Il1B, Nlrp3, and Casp1; activation of NF-kappaB; release of IL1beta; and cleavage of CASP1. Lactic Acid toll-like receptor 4 Mus musculus