Title : Non-neuronal muscarinic receptor activation prevents apoptosis of endothelial cells induced by homocysteine.

Pub. Date : 2013 Nov

PMID : 24654541






1 Functional Relationships(s)
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1 These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors. Arecoline Wistar clone pR53P1 p53 pseudogene Rattus norvegicus