Title : 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144.

Pub. Date : 2014 Jun

PMID : 24642088






1 Functional Relationships(s)
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1 HAECs treated with 7-KC showed significant reductions of IDH2 mRNA and protein levels and enzyme activity, leading to decreased NADPH concentration and an increased ratio of reduced-to-oxidized glutathione in the mitochondria. NADP isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens