Pub. Date : 2014 May 1
PMID : 24631288
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin also strongly inhibited AKT activation, leading to suppression of beta-catenin activity and the expression of its targets, survivin and cyclin D1. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Both insulin treatment and AKT overexpression markedly increased p-beta-catenin and survivin levels, even in the presence of gefitinib and simvastatin. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Overall, these data indicate that simvastatin may overcome EGFR-TKI resistance in T790M mutant NSCLCs via an AKT/beta-catenin signaling-dependent down-regulation of survivin and apoptosis induction. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |