Title : Liver nuclear NADPH-cytochrome P-450 reductase may be involved in redox cycling of bleomycin-Fe(III), oxy radical formation and DNA damage.

Pub. Date : 1987

PMID : 2462531






1 Functional Relationships(s)
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1 When NADPH-cytochrome P-450 reductase isolated from rat liver microsomes was aerobically incubated with bleomycin, FeCl3, NADPH and DNA parallel NADPH and oxygen were consumed and malondialdehyde was formed. ferric chloride cytochrome p450 oxidoreductase Rattus norvegicus