Title : Microwave-assisted synthesis of novel purine nucleosides as selective cholinesterase inhibitors.

Pub. Date : 2014 Apr 21

PMID : 24604285






1 Functional Relationships(s)
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1 Some of the nucleosides were far more potent than the drug galantamine, and the most promising competitive and selective BChE inhibitor, the N(7)-linked 2-acetamido-alpha-D-mannosylpurine, showed a Ki of 50 nM and a selectivity factor of 340 fold for BChE over AChE. Nucleosides acetylcholinesterase (Cartwright blood group) Homo sapiens