Title : Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models.

Pub. Date : 2014 Mar 5

PMID : 24597901






2 Functional Relationships(s)
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1 Here we assessed the anti-BACE-1 and behavioral activities of curcuminoids from rhizomes of Curcuma longa (Zingiberaceae), diarylalkyls curcumin (CCN), demethoxycurcumin (DMCCN), and bisdemethoxycurcumin (BDMCCN) against AD Drosophila melanogaster models. Curcumin beta-secretase 1 Homo sapiens
2 RESULTS: BDMCCN has the strongest inhibitory activity toward BACE-1 with 17 muM IC50, which was 20 and 13 times lower than those of CCN and DMCCN respectively. Curcumin beta-secretase 1 Homo sapiens