Title : Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.

Pub. Date : 2014 Apr 9

PMID : 24594525






1 Functional Relationships(s)
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1 In vitro tests revealed that compounds 3 and 5, which bear a nitrate moiety in the molecule, showed a potent inhibition activity towards AChE and compound 3 showed a good Abeta42 aggregation inhibitory activity. Nitrates acetylcholinesterase (Cartwright blood group) Homo sapiens