Title : Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target Akt with the clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer.

Pub. Date : 2014 Mar 27

PMID : 24592939






2 Functional Relationships(s)
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1 In this study, we describe a triethanolamine-core poly(amidoamine) dendrimer which forms stable nanoparticles with the Akt siRNA, protects siRNA against RNase digestion, and is highly effective for initiating Akt target-gene silencing both in vitro and in vivo, while being minimally toxic. triethanolamine AKT serine/threonine kinase 1 Homo sapiens
2 In this study, we describe a triethanolamine-core poly(amidoamine) dendrimer which forms stable nanoparticles with the Akt siRNA, protects siRNA against RNase digestion, and is highly effective for initiating Akt target-gene silencing both in vitro and in vivo, while being minimally toxic. triethanolamine AKT serine/threonine kinase 1 Homo sapiens