Title : Tetrandrine suppresses pro-inflammatory mediators in PMA plus A23187-induced HMC-1 cells.

Pub. Date : 2014 May

PMID : 24589569






2 Functional Relationships(s)
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1 TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187. tetrandrine interleukin 6 Homo sapiens
2 Furthermore, TET suppressed the expression of TNF-alpha, IL-8, IL-6 and COX-2 through suppression of the ERK1/2, JNK1/2, IkappaBalpha degradation and phosphorylation, and NF-kappaB activation. tetrandrine interleukin 6 Homo sapiens