Pub. Date : 2014
PMID : 24586933
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study assessed the role of mitogen-activated protein kinases (MAPKs), in particular the extracellular signal-regulated kinase (ERK), in ROS-induced signal transduction leading to lymphocyte parthanatos. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The present study assessed the role of mitogen-activated protein kinases (MAPKs), in particular the extracellular signal-regulated kinase (ERK), in ROS-induced signal transduction leading to lymphocyte parthanatos. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | ROS-generating myeloid cells and exogenous H2O2 triggered PARP 1-dependent accumulation of poly ADP-ribose (PAR), which was prevented by ERK pathway inhibitors. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Our findings are suggestive of a role for ERK1/2 in ROS-induced lymphocyte parthanatos, and that the ERK axis may provide a therapeutic target for the protection of lymphocytes against oxidative stress. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |