Title : Topoisomerase inhibitors modulate gene expression of B-cell translocation gene 2 and prostate specific antigen in prostate carcinoma cells.

Pub. Date : 2014

PMID : 24586533






4 Functional Relationships(s)
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1 CPT or DOX also downregulated the protein expressions of androgen receptor (AR) and PSA. Doxorubicin kallikrein related peptidase 3 Homo sapiens
2 Transient gene expression assays suggested that CPT or DOX"s attenuation of PSA promoter activity is dependent on both the androgen and p53 response elements within of the PSA promoter. Doxorubicin kallikrein related peptidase 3 Homo sapiens
3 Transient gene expression assays suggested that CPT or DOX"s attenuation of PSA promoter activity is dependent on both the androgen and p53 response elements within of the PSA promoter. Doxorubicin kallikrein related peptidase 3 Homo sapiens
4 The CPT and DOX block the PSA gene expression by upregulation of p53 activity and downregulation of androgen receptor activity. Doxorubicin kallikrein related peptidase 3 Homo sapiens