Pub. Date : 2014 May
PMID : 24584901
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | However, the effects of resveratrol on SIRT1, PPARgamma and PPARalpha expression and lipid accumulation were reversed when the cells were pre-treated with compound C. Resveratrol downregulated the mRNA expression of MCP-1 in a dose-dependent manner and LPS upregulate its expression in a time-dependent manner. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | However, the effects of resveratrol on SIRT1, PPARgamma and PPARalpha expression and lipid accumulation were reversed when the cells were pre-treated with compound C. Resveratrol downregulated the mRNA expression of MCP-1 in a dose-dependent manner and LPS upregulate its expression in a time-dependent manner. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | MCP-1 expression induced by LPS was inhibited by resveratrol at both the transcriptional and translational level. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | These data suggest that resveratrol inhibits foam cell formation by regulating the expression of MCP-1 and activating the AMPK-SIRT1-PPAR signaling pathway; thus, resveratrol may be a novel therapeutic agent for atherosclerosis. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |
| 6 | These data suggest that resveratrol inhibits foam cell formation by regulating the expression of MCP-1 and activating the AMPK-SIRT1-PPAR signaling pathway; thus, resveratrol may be a novel therapeutic agent for atherosclerosis. | Resveratrol | C-C motif chemokine ligand 2 | Homo sapiens |