Title : The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells.

Pub. Date : 2014 Feb 27

PMID : 24577083






1 Functional Relationships(s)
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1 Collectively, our findings demonstrate that selenite caused CYLD upregulation via LEF1 and cIAP downregulation, both of which contribute to the degradation of ubiquitin chains on RIP1 and subsequent caspase-8 activation and apoptosis. Selenious Acid caspase 8 Homo sapiens