Pub. Date : 2014
PMID : 24563687
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HIF-alpha is degraded under normoxic conditions by proline hydroxylation, which allows for recognition and ubiquitination by the von-Hippel-Lindau (VHL) E3 ligase complex. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |
| 2 | HIF-alpha is degraded under normoxic conditions by proline hydroxylation, which allows for recognition and ubiquitination by the von-Hippel-Lindau (VHL) E3 ligase complex. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |
| 3 | We found that HIF-1alpha proline-hydroxylated at both VHL binding sites (Pro402 and Pro564), was present in hypoxic regions of a wide range of tumours, tumour xenografts and in moderately hypoxic cells in vitro. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |