Title : Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.

Pub. Date : 2014 Mar 6

PMID : 24560924






1 Functional Relationships(s)
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1 Structural analysis of oncogenic M918T and wild-type RET kinase domains reveal a cis-inhibitory mechanism involving tethering contacts between the glycine-rich loop, activation loop, and alphaC-helix. Glycine ret proto-oncogene Homo sapiens