Title : Regorafenib in metastatic colorectal cancer.

Pub. Date : 2014 Mar

PMID : 24559322






1 Functional Relationships(s)
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1 Regorafenib is an oral multikinase inhibitor that blocks the activity of protein kinases involved in the regulation of tumor angiogenesis (VEGFR1, 2, 3; angiopoietin-1 receptor), oncogenesis (stem cell growth factor receptor; RET; BRAF including BRAFV600E), and tumor microenvironment (PDGFR-beta and FGFR). regorafenib platelet derived growth factor receptor beta Homo sapiens