Pub. Date : 1988 May
PMID : 2455846
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of extracellular Ca2+ and related ions on the cardiac action of milrinone. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 2 | The biphasic single dose, dose-response curve of milrinone was sensitive to [Ca2+]0. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 3 | The inotropic response to milrinone in contrast to norepinephrine is highly sensitive to the extracellular [Ca2+]0. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 4 | At low [Ca2+]0 of 0.15 mM milrinone could produce a negative inotropic effect. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 5 | The positive inotropic effect of milrinone was proportional to [Ca2+]0 up to 2.7 mM. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 6 | With [Ca2+]0 above 3.6 mM and low [Na+]0, the inotropic response to milrinone was reduced. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 7 | The results are discussed and it is suggested that milrinone acts on Ca2+ channels in the sarcolemma and intracellularly by increasing cyclic AMP which activates Ca2+ release and uptake from the sarcoplasmic reticulum. | Milrinone | carbonic anhydrase 2 | Homo sapiens |
| 8 | The results are discussed and it is suggested that milrinone acts on Ca2+ channels in the sarcolemma and intracellularly by increasing cyclic AMP which activates Ca2+ release and uptake from the sarcoplasmic reticulum. | Milrinone | carbonic anhydrase 2 | Homo sapiens |