Pub. Date : 2015 Jan
PMID : 24555516
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhancement of morphine analgesia and prevention of morphine tolerance by downregulation of beta-arrestin 2 with antigene RNAs in mice. | Morphine | arrestin, beta 2 | Mus musculus |
| 2 | Enhancement of morphine analgesia and prevention of morphine tolerance by downregulation of beta-arrestin 2 with antigene RNAs in mice. | Morphine | arrestin, beta 2 | Mus musculus |
| 3 | In this study, antigene RNAs (agRNAs), which could selectively target gene transcription start sites and potently inhibit gene expression, were used to downregulate the expression of beta-arrestin 2 to investigate its effects on morphine analgesia and tolerance in mice. | Morphine | arrestin, beta 2 | Mus musculus |
| 4 | Mice treated with beta-arrestin 2 agRNAs showed enhanced analgesic effects in response to morphine and failed to develop antinociceptive tolerance. | Morphine | arrestin, beta 2 | Mus musculus |
| 5 | These results suggest that inhibition of beta-arrestin 2 in the brain with specific agRNAs can improve morphine efficacy, and consequently provide us a useful strategy for treatment of chronic intractable pain and morphine tolerance in vivo. | Morphine | arrestin, beta 2 | Mus musculus |
| 6 | These results suggest that inhibition of beta-arrestin 2 in the brain with specific agRNAs can improve morphine efficacy, and consequently provide us a useful strategy for treatment of chronic intractable pain and morphine tolerance in vivo. | Morphine | arrestin, beta 2 | Mus musculus |