Title : Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells.

Pub. Date : 2014 Feb 15

PMID : 24553354






1 Functional Relationships(s)
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1 Moreover, Chel A-induced p53 protein accumulation and activation required ATR/Chk2 axis, which is distinct from the mechanism that we have most recently identified the Chk1/p53-dependent apoptotic response by Chel A in normal mouse epidermal Cl41 cells. chel a checkpoint kinase 2 Mus musculus