Pub. Date : 2014
PMID : 24552824
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target. | NAD | tumor protein p53 | Homo sapiens |
| 2 | This notion led us to examine whether p53 can regulate NAD(+) biosynthesis in the cell. | NAD | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling. | NAD | tumor protein p53 | Homo sapiens |
| 4 | Our demonstration that p53 modulates cellular NAD(+) synthesis is congruent with p53"s emerging role as a key regulator of metabolism and related cell fate. | NAD | tumor protein p53 | Homo sapiens |
| 5 | Our demonstration that p53 modulates cellular NAD(+) synthesis is congruent with p53"s emerging role as a key regulator of metabolism and related cell fate. | NAD | tumor protein p53 | Homo sapiens |