Title : A novel design of combining the angiotensin converting enzyme (ACE) inhibitor captopril with the angiotensin receptor blocker (ARB) losartan using homo coupling via PEG diacid linker.

Pub. Date : 2013 Dec

PMID : 24552291






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Although captopril and losartan work in the same system by blocking the effect of angiotensin II they have different action sites and mechanisms some patents are also discussed. Captopril angiotensinogen Homo sapiens
2 Losartan blocks the AT1 receptor which is expressed on the cell surface, while captopril inhibits ACE, preventing production of angiotensin II, which is present in both the plasma and on the cell surface, especially on endothelial and smooth muscle cells. Captopril angiotensinogen Homo sapiens