Pub. Date : 2014
PMID : 24551237
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 2 | Similarly, hydroxycinnamic acids and derivatives (chlorogenic, cinnamic, and ferulic acids) combined with leucine/HMB increased FAO (300-1300%, p<0.01), AMPK activity (50-150%, p<0.01), and Sirt1 activity (~70%, p<0.001). | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 3 | Thus, the six-carbon ring structure bound to a carboxylic group seems to be a necessary element for leucine/HMB synergy with other stilbenes and hydroxycinnamic acids to stimulate AMPK/Sirt1 dependent FAO; these effects occur at concentrations that produce no independent effects and are readily achievable via oral administration. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |