Pub. Date : 2014 Oct
PMID : 24535918
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously identified that activation of the aryl hydrocarbon receptor (AhR) by 3-methylcholanthrene (3MC) exerts antiproliferative and antimigratory effects on human umbilical vein endothelial cells (HUVECs) through the upregulation of p21/p27 transcription and RhoA activation. | Methylcholanthrene | H3 histone pseudogene 16 | Homo sapiens |
| 2 | We previously identified that activation of the aryl hydrocarbon receptor (AhR) by 3-methylcholanthrene (3MC) exerts antiproliferative and antimigratory effects on human umbilical vein endothelial cells (HUVECs) through the upregulation of p21/p27 transcription and RhoA activation. | Methylcholanthrene | H3 histone pseudogene 16 | Homo sapiens |
| 3 | Our results indicated that 3MC reduced the phosphorylation of p21/p27 through AhR/RhoA/PTEN-mediated PI3K/Akt inactivation, which reduced cytosolic p21/p27 retention, causing RhoA activation through positive feedback. | Methylcholanthrene | H3 histone pseudogene 16 | Homo sapiens |
| 4 | Our results indicated that 3MC reduced the phosphorylation of p21/p27 through AhR/RhoA/PTEN-mediated PI3K/Akt inactivation, which reduced cytosolic p21/p27 retention, causing RhoA activation through positive feedback. | Methylcholanthrene | H3 histone pseudogene 16 | Homo sapiens |
| 5 | Downregulation of p21/p27 by siRNA, and cytosolic p21/p27 by the nuclear export blocker leptomycin B, further reduced cell migration in the 3MC-treated cells. | Methylcholanthrene | H3 histone pseudogene 16 | Homo sapiens |
| 6 | Downregulation of p21/p27 by siRNA, and cytosolic p21/p27 by the nuclear export blocker leptomycin B, further reduced cell migration in the 3MC-treated cells. | Methylcholanthrene | H3 histone pseudogene 16 | Homo sapiens |